Vitamin B6 decreases the therapeutic effect of levodopa because it acts as a cofactor which enhances peripheral conversion of levodopa to dopamine so that less is available for transport into the brain. Dopamine antagonists such as the phenothiazines, butyrophenones and reserpine (which depletes dopamine stores) counteract the effect of levodopa. MAO inhibitors prevent dopamine breakdown, increasing dopaminergic effects unpredictably. leading to a hypertensive crisis or hyperpyrexia. This is a dangerous interaction.
This reduces the patient’s mental stress, Autism Symptoms and probably alters his physiological response to stress. With a well-sedated patient. induction of anaesthesia is smoother and the amount of anaesthetic used is much less. There are various types of anxiety-reducing premedicants. The major groups include anxiolytics/sedatives/hypnotics, opiates and their derivatives. The same applies to antihistamines and major tranquillizers.
These are derived mainly from two large pharmacological families namely the barbiturates and the benzodiazepines.
